Based on limited published evidence, CCDC198 (FAME) is a membrane-bound protein involved in metabolic regulation and energy homeostasis. UniProt annotations suggest roles in tuning metabolism, energy expenditure, and excretion. Recent research 1 demonstrates that CCDC198 knockout animals exhibit altered body weight and decreased energy expenditure, with associations to human body mass index. The protein localizes to kidney vesicular and plasma membranes, interacts with ferritin, and influences renal albumin excretion and blood ferritin levels, indicating involvement in both metabolic and kidney physiology processes.