PPRC1 (peroxisome proliferator-activated receptor gamma coactivator-related protein 1) functions as a transcriptional coactivator controlling mitochondrial biogenesis and energy metabolism. PPRC1 activates genes regulated by transcription factors NRF1 and CREB, coordinating nuclear-encoded mitochondrial proteins and oxidative phosphorylation capacity 12. Mechanistically, PPRC1 can be phosphorylated by PAK1 kinase and stabilized through USP12-mediated deubiquitination, enabling its interaction with histone acetyltransferases p300/CBP and transcription factors like AP1 to enhance target gene expression 3. PPRC1 regulates renal mercury excretion, with natural genetic variations affecting expression levels 4. Clinically, PPRC1 demonstrates significant disease relevance: elevated PPRC1 expression correlates with poor prognosis across multiple cancers including acute myeloid leukemia, ovarian cancer, and hepatocellular carcinoma, with high expression predicting shortened overall survival 125. In multiple myeloma, PPRC1 functions as an independent prognostic biomarker sustaining mitochondrial oxidative phosphorylation and supporting malignant cell proliferation 5. Additionally, PPRC1 mutations associate with premature ovarian failure through mechanisms involving granulosa cell apoptosis 6. These findings establish PPRC1 as a key metabolic regulator with emerging therapeutic potential in cancer and metabolic disorders.