GPR82 is an orphan G protein-coupled receptor located on the X chromosome X emerging roles in metabolic regulation and immune function. Based on phylogenetic analysis, GPR82 is predicted to bind N-arachidonylglycine 1. Functionally, GPR82 influences energy homeostasis through regulation of food intake and body weight. GPR82-deficient mice exhibit reduced body weight, decreased food intake, lower serum triacylglyceride levels, and improved insulin sensitivity and glucose tolerance under Western diet conditions, suggesting GPR82 acts as a "thrifty gene" regulating energy balance independently of changes in metabolic rate 2. GPR82 expression is tissue-specific and altered in metabolic syndrome; expression levels differ between genetic (Zucker rats) and diet-induced models across brain, heart, aorta, liver, and kidney 3. Clinically, GPR82 dysregulation is associated with metabolic disease pathogenesis. Recent evidence indicates GPR82 upregulation in peripheral eosinophils of COPD patients compared to asthma patients, suggesting differential roles in obstructive airway disease pathobiology 4. Additionally, GPR82 expression is regulated downstream of the serotonin signaling pathway in response to mind-body therapeutic interventions for essential hypertension 5. These findings position GPR82 as a potential therapeutic target for metabolic and cardiovascular disorders.