CEP72 is a centriolar satellite protein that plays crucial roles in centrosome function and microtubule organization. It serves as a key regulatory component for recruiting essential centrosomal proteins, including γ-tubulin ring complexes (γ-TuRCs), AKAP9, and KIZ to the centrosome 1. CEP72 interacts with PCM1 and Cep290 within centriolar satellites and is required for proper recruitment of BBS proteins to primary cilia, indicating its importance in ciliary function 2. The protein works in conjunction with the MLL/WDR5 complex to regulate microtubule nucleation and spindle formation during mitosis, with loss of CEP72 leading to spindle defects and chromosome 5 1. Clinically, CEP72 has emerged as a disease-relevant biomarker, with overexpression associated with poor prognosis in multiple myeloma 3 and altered expression linked to spinocerebellar ataxia progression 4. Additionally, genetic variants in CEP72 contribute to vincristine-induced peripheral neuropathy in cancer patients 5. The protein's dysfunction is implicated in various ciliopathies and centrosome-related disorders, highlighting its critical role in cellular organization and human health 6.