CLPSL1 — colipase like 1

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

7PubMed Papers

#17,902 · top 92% of 19K genes

16Diseases

top 92%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

enzyme activator activitydigestionlipid catabolic processextracellular regionresponse to statinHashimoto's thyroiditispsoriasis vulgarisHematemesis

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

colipase like 1

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations16

response to statinOpen Targets

0.16Weak

Hashimoto's thyroiditisOpen Targets

0.14Weak

psoriasis vulgarisOpen Targets

0.14Weak

HematemesisOpen Targets

0.06Suggestive

celiac diseaseOpen Targets

0.04Suggestive

ulcerative colitisOpen Targets

0.03Suggestive

thyroid diseaseOpen Targets

0.03Suggestive

non-small cell lung carcinomaOpen Targets

0.01Suggestive

triple-negative breast cancerOpen Targets

0.01Suggestive

breast cancerOpen Targets

0.00Suggestive

colorectal carcinomaOpen Targets

0.00Suggestive

neoplasmOpen Targets

0.00Suggestive

Laurence-Moon syndromeOpen Targets

0.00Suggestive

Hereditary breast cancerOpen Targets

0.00Suggestive

hereditary breast carcinomaOpen Targets

0.00Suggestive

ovarian serous cystadenocarcinomaOpen Targets

0.00Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Brain

100%

Bone Marrow

29%

Ovary

Lung

Liver

Heart

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt A2RUU4

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ConstraintgnomAD v4.1

LOEUFⓘ

1.87LoF Tolerant

pLIⓘ

0.00Tolerant

Observed/Expected LoF1.24 [0.73–1.87]

Rankings2 dim

Where CLPSL1 stands among ~20K protein-coding genes

#17,806of 20,598
Most Researched7
#16,988of 17,882
Most Constrained (LOEUF)1.87