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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
H2BC17
H2B clustered histone 17
Chromosome 6 Β· 6p22.1
NCBI Gene: 8348Ensembl: ENSG00000274641.2HGNC: HGNC:4758UniProt: P23527
60PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Hub Gene
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
nucleusprotein bindinginnate immune response in mucosachromatin organizationviral diseaseinfectious diseasebreast carcinomacancer
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

H2B clustered histone 17

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
infectious diseaseOpen Targets
0.50Moderate
viral diseaseOpen Targets
0.50Moderate
breast carcinomaOpen Targets
0.39Weak
cancerOpen Targets
0.37Weak
dengue diseaseOpen Targets
0.37Weak
melanomaOpen Targets
0.37Weak
actinic keratosisOpen Targets
0.04Suggestive
sebaceous of Jadassohn nevusOpen Targets
0.04Suggestive
central nervous system cancerOpen Targets
0.03Suggestive
non-small cell lung carcinomaOpen Targets
0.02Suggestive
lung adenocarcinomaOpen Targets
0.01Suggestive
breast cancerOpen Targets
0.01Suggestive
systemic lupus erythematosusOpen Targets
0.01Suggestive
glioblastoma multiformeOpen Targets
0.01Suggestive
LeishmaniasisOpen Targets
0.01Suggestive
laryngotracheoesophageal cleftOpen Targets
0.01Suggestive
COVID-19Open Targets
0.00Suggestive
gastroesophageal reflux diseaseOpen Targets
0.00Suggestive
infectionOpen Targets
0.00Suggestive
osteoporosisOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
H2BC26Shared pathway100%H2AC20Protein interaction100%H3-4Protein interaction100%H3C13Protein interaction100%H3C12Protein interaction100%H2BC5Protein interaction100%
Tissue Expression6 tissues
Bone Marrow
100%
Brain
58%
Lung
38%
Liver
23%
Ovary
0%
Heart
0%
Gene Interaction Network
Click a node to explore
H2BC17H2BC26H2AC20H3-4H3C13H3C12H2BC5
PROTEIN STRUCTURE
Preparing viewer…
PDB7WLP Β· 2.29 Γ… Β· X-ray
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
1.95LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF1.72 [1.00–1.95]
RankingsWhere H2BC17 stands among ~20K protein-coding genes
  • #7,667of 20,598
    Most Researched60
  • #17,696of 17,882
    Most Constrained (LOEUF)1.95
Genes detectedH2BC17
Sources retrieved0 papers
Response timeβ€”