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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
H2BC26
H2B clustered histone 26
Chromosome 1 Β· 1q42.13
NCBI Gene: 128312Ensembl: ENSG00000196890.5HGNC: HGNC:20514UniProt: Q8N257
83PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
nucleusstructural constituent of chromatininnate immune response in mucosachromatin organizationinfectious diseaseviral diseasebreast carcinomacancer
✦AI Summary

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H2B clustered histone 26

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
infectious diseaseOpen Targets
0.50Moderate
viral diseaseOpen Targets
0.50Moderate
breast carcinomaOpen Targets
0.38Weak
cancerOpen Targets
0.37Weak
dengue diseaseOpen Targets
0.37Weak
melanomaOpen Targets
0.37Weak
Abnormality of the skeletal systemOpen Targets
0.02Suggestive
colorectal carcinomaOpen Targets
0.01Suggestive
metastatic melanomaOpen Targets
0.01Suggestive
lung adenocarcinomaOpen Targets
0.01Suggestive
COVID-19Open Targets
0.01Suggestive
systemic lupus erythematosusOpen Targets
0.01Suggestive
papillary thyroid carcinomaOpen Targets
0.01Suggestive
LeishmaniasisOpen Targets
0.01Suggestive
Alzheimer diseaseOpen Targets
0.00Suggestive
infectionOpen Targets
0.00Suggestive
neoplasmOpen Targets
0.00Suggestive
visceral LeishmaniasisOpen Targets
0.00Suggestive
readingOpen Targets
0.00Suggestive
Cornelia de Lange syndromeOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
H2BC5Shared pathway100%H2BC17Shared pathway100%H2BC18Shared pathway100%H2BC3Shared pathway80%H2BC13Shared pathway80%H2BC15Shared pathway80%
Tissue Expression6 tissues
Brain
100%
Lung
28%
Bone Marrow
27%
Ovary
26%
Liver
17%
Heart
9%
Gene Interaction Network
Click a node to explore
H2BC26H2BC5H2BC17H2BC18H2BC3H2BC13H2BC15
PROTEIN STRUCTURE
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PDB6BIZ Β· 2.10 Γ… Β· X-ray
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
1.91LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF1.36 [0.80–1.91]
RankingsWhere H2BC26 stands among ~20K protein-coding genes
  • #5,730of 20,598
    Most Researched83
  • #17,304of 17,882
    Most Constrained (LOEUF)1.91
Genes detectedH2BC26
Sources retrieved0 papers
Response timeβ€”