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GeneE
3 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
HAUS2
HAUS augmin like complex subunit 2
Chromosome 15 Β· 15q15.2
NCBI Gene: 55142Ensembl: ENSG00000137814.12HGNC: HGNC:25530UniProt: H3BP16
52PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingcentrosome cyclespindle assemblycentrosomeSjogren syndromediffuse large B-cell lymphomaPlasmodium falciparum malariaataxia telangiectasia
✦AI Summary

HAUS2 is a core component of the HAUS augmin-like complex that functions primarily in mitotic spindle assembly and centrosome integrity maintenance 1. As part of the Augmin/HAUS complex, HAUS2 facilitates microtubule nucleation during cell division 1. The complex is essential for proper centrosome function, with combined knockdown of HAUS2 with HAUS5 or HAUS4 causing centrosome fragmentation and cell lethality in neural progenitor cells 1. HAUS2 expression is significantly elevated in low-grade gliomas compared to normal brain tissue, and its expression level is associated with glioma prognosis 2. The gene has been included in prognostic risk models for predicting patient outcomes in low-grade gliomas 2. Additionally, HAUS2 is subject to adenosine-to-inosine RNA editing in the brain, with editing levels correlating with gene expression; alterations in this editing have been observed in sepsis-associated encephalopathy 3. These findings suggest HAUS2 plays critical roles in both normal mitotic processes and in pathological contexts involving glioma development and neurological disease.

Sources cited
1
HAUS2 is part of the Augmin/HAUS complex essential for centrosome function and microtubule nucleation; combined knockdown of HAUS2 with HAUS5 or HAUS4 causes centrosome fragmentation
PMID: 28596487
2
HAUS2 mRNA expression is significantly elevated in low-grade gliomas and is included in prognostic risk models for predicting glioma patient outcomes
PMID: 37161065
3
HAUS2 undergoes adenosine-to-inosine RNA editing in the brain with editing levels correlating to gene expression; alterations observed in sepsis-associated encephalopathy
PMID: 35559016
⚠Limited data available β€” This gene has 3 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
Sjogren syndromeOpen Targets
0.27Weak
diffuse large B-cell lymphomaOpen Targets
0.01Suggestive
Plasmodium falciparum malariaOpen Targets
0.01Suggestive
ataxia telangiectasiaOpen Targets
0.01Suggestive
neoplasmOpen Targets
0.01Suggestive
Pick diseaseOpen Targets
0.01Suggestive
Alzheimer diseaseOpen Targets
0.00Suggestive
SepsisOpen Targets
0.00Suggestive
hepatitis B virus infectionOpen Targets
0.00Suggestive
glioblastomaOpen Targets
0.00Suggestive
oligodendrogliomaOpen Targets
0.00Suggestive
ependymomaOpen Targets
0.00Suggestive
astrocytomaOpen Targets
0.00Suggestive
multiple myelomaOpen Targets
0.00Suggestive
acute myeloid leukemiaOpen Targets
0.00Suggestive
esophageal cancerOpen Targets
0.00Suggestive
gastric cancerOpen Targets
0.00Suggestive
melanomaOpen Targets
0.00Suggestive
sarcomaOpen Targets
0.00Suggestive
thyroid cancer, nonmedullary, 1Open Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
PCM1Protein interaction100%TUBG1Protein interaction100%HAUS3Protein interaction92%HAUS7Protein interaction92%PCNTProtein interaction89%HAUS1Protein interaction85%
Tissue Expression6 tissues
Bone Marrow
100%
Brain
51%
Heart
31%
Lung
24%
Ovary
20%
Liver
16%
Gene Interaction Network
Click a node to explore
HAUS2PCM1TUBG1HAUS3HAUS7PCNTHAUS1
PROTEIN STRUCTURE
Preparing viewer…
PDB7SQK Β· 8.00 Γ… Β· EM
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
1.86LoF Tolerant
pLIβ“˜
0.33Tolerant
Observed/Expected LoF0.00 [0.00–1.86]
RankingsWhere HAUS2 stands among ~20K protein-coding genes
  • #8,558of 20,598
    Most Researched52
  • #16,907of 17,882
    Most Constrained (LOEUF)1.86
Genes detectedHAUS2
Sources retrieved3 papers
Response timeβ€”
πŸ“„ Sources
3
1
ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5.
PMID: 28596487
Oncotarget Β· 2017
1.00
2
A prognostic model based on the Augmin family genes for LGG patients.
PMID: 37161065
Sci Rep Β· 2023
0.67
3
Brain Epitranscriptomic Analysis Revealed Altered A-to-I RNA Editing in Septic Patients.
PMID: 35559016
Front Genet Β· 2022
0.33