3 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
βGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
52PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITYβ Experimental GO Evidenceβ Swiss-Prot Reviewed
protein bindingcentrosome cyclespindle assemblycentrosomeSjogren syndromediffuse large B-cell lymphomaPlasmodium falciparum malariaataxia telangiectasia
HAUS2 is a core component of the HAUS augmin-like complex that functions primarily in mitotic spindle assembly and centrosome integrity maintenance 1. As part of the Augmin/HAUS complex, HAUS2 facilitates microtubule nucleation during cell division 1. The complex is essential for proper centrosome function, with combined knockdown of HAUS2 with HAUS5 or HAUS4 causing centrosome fragmentation and cell lethality in neural progenitor cells 1. HAUS2 expression is significantly elevated in low-grade gliomas compared to normal brain tissue, and its expression level is associated with glioma prognosis 2. The gene has been included in prognostic risk models for predicting patient outcomes in low-grade gliomas 2. Additionally, HAUS2 is subject to adenosine-to-inosine RNA editing in the brain, with editing levels correlating with gene expression; alterations in this editing have been observed in sepsis-associated encephalopathy 3. These findings suggest HAUS2 plays critical roles in both normal mitotic processes and in pathological contexts involving glioma development and neurological disease.
1
HAUS2 is part of the Augmin/HAUS complex essential for centrosome function and microtubule nucleation; combined knockdown of HAUS2 with HAUS5 or HAUS4 causes centrosome fragmentation
PMID: 285964872
HAUS2 mRNA expression is significantly elevated in low-grade gliomas and is included in prognostic risk models for predicting glioma patient outcomes
PMID: 371610653
HAUS2 undergoes adenosine-to-inosine RNA editing in the brain with editing levels correlating to gene expression; alterations observed in sepsis-associated encephalopathy
PMID: 35559016β Limited data available β This gene has 3 indexed publications. Summary and analysis may be incomplete.
Sjogren syndromeOpen Targets
diffuse large B-cell lymphomaOpen Targets
Plasmodium falciparum malariaOpen Targets
ataxia telangiectasiaOpen Targets
Alzheimer diseaseOpen Targets
hepatitis B virus infectionOpen Targets
oligodendrogliomaOpen Targets
multiple myelomaOpen Targets
acute myeloid leukemiaOpen Targets
esophageal cancerOpen Targets
gastric cancerOpen Targets
thyroid cancer, nonmedullary, 1Open Targets
No pathogenic variants reported on ClinVar for this gene.