HAUS5 is a core component of the HAUS augmin-like complex that mediates mitotic spindle assembly and centrosome integrity maintenance 1. As part of the augmin complex, HAUS5 facilitates microtubule nucleation along the mitotic spindle and is essential for completion of cytokinesis. The complex demonstrates heightened functional importance in glioblastoma stem-like cells (GSCs), where HAUS5 knockdown causes mitotic arrest, centrosome fragmentation, and loss of self-renewal capacity 1. Clinically, HAUS5 expression is significantly elevated in low-grade gliomas (LGG) and hepatocellular carcinoma (LIHC), where high expression correlates with poor prognosis 2 3. In LIHC specifically, HAUS5 functions as an independent prognostic risk factor associated with DNA replication and cell cycle dysregulation 3. HAUS5 knockdown reduces hepatoma cell proliferation in vitro, supporting its role as a positive regulator of cancer progression 3. Additionally, HAUS5 expression correlates with immune cell infiltration in both gliomas and liver cancer 2 3, suggesting involvement in tumor immunoregulation. These findings position HAUS5 as both a pan-cancer prognostic biomarker and potential therapeutic target, particularly in glioblastoma and hepatocellular carcinoma.