HAUS7 is an X-linked component of the HAUS augmin-like complex essential for microtubule organization and cellular division. As part of the HAUS complex, HAUS7 contributes to mitotic spindle assembly, centrosome integrity maintenance, and cytokinesis completion 1. Beyond canonical mitotic functions, HAUS7 serves as a DOCK3 binding partner that facilitates axon regeneration through microtubule assembly in neuronal contexts 1. DOCK3-mediated phosphorylation at Y562 triggers HAUS7 dissociation, enabling microtubule formation critical for axon elongation following optic nerve injury 1. Clinically, HAUS7 mutations associate with severe male infertility, with a hemizygous variant (c.G386T:p.G129V) identified in brothers with severe oligozoospermia, suggesting HAUS7's role in meiotic maturation and germ cell chromosome X 2. In contrast to other Augmin family members elevated in low-grade gliomas, HAUS7 expression is reduced in glioma tissues and correlates with better prognosis 3. Additionally, HAUS7 deletions occur in primary ovarian insufficiency patients, indicating involvement in meiotic DNA repair 4. HAUS7 has been identified as a potential therapeutic target in head and neck squamous cell carcinoma 5, though further validation is needed to establish clinical utility.