HAUS3 is a core component of the HAUS augmin-like complex essential for mitotic spindle assembly and centrosome integrity. It functions in microtubule nucleation and organization at the microtubule organizing center, contributing to proper spindle dynamics and completion of cytokinesis 12. Mechanistically, HAUS3 regulates G2/M phase transition by controlling phosphorylation of PLK1-T210 and modulating Cdk1/cyclin B1 complex activity, while coordinating α-tubulin and γ-tubulin expression for proper mitotic progression 1. During hematopoiesis, HAUS3 (orthologous to zebrafish samba) is cell-autonomously required for hematopoietic stem/progenitor cell maintenance and development by regulating cell cycle progression 3. Clinically, HAUS3 overexpression associates with poor prognosis across multiple malignancies. In hepatocellular carcinoma, high HAUS3 expression correlates with large tumor size and multiplicity, serving as an independent prognostic factor for overall survival 1. Similarly, in low-grade glioma, elevated HAUS3 expression predicts poor prognosis and correlates with increased immune cell infiltration 2. HAUS3 mutations have been detected in metastatic breast cancer, suggesting involvement in tumor progression 4. These findings position HAUS3 as a potential prognostic biomarker and therapeutic target in cancer.