HAUS4 is a core component of the HAUS augmin-like complex that regulates microtubule organization during cell division. HAUS4 functions as part of a multi-protein complex essential for mitotic spindle assembly, centrosome integrity maintenance, and cytokinesis completion 1. The complex facilitates microtubule nucleation along the mitotic spindle through microtubule minus-end binding activities 2. Disease relevance extends across multiple pathologies. HAUS4 knockdown triggers cellular senescence markers including p16/p21 activation, cell cycle arrest, and morphological changes characteristic of senescent cells 3. In glioblastoma stem-like cells, HAUS4 is critical for maintaining centrosome integrity; its depletion causes centrosome fragmentation and loss of self-renewal capacity 1. In low-grade gliomas, low HAUS4 expression correlates with poor patient prognosis 2. HAUS4 also plays roles in cell proliferation regulation under stress conditions, with downregulation observed under simulated microgravity affecting hepatic immune cell proliferation 4. Notably, circulating HAUS4-derived circular RNA (circ-HAUS4) is dysregulated in Alzheimer's disease and correlates with cognitive decline and tau pathology, suggesting potential disease biomarker utility 5. Clinically, HAUS4 expression levels provide prognostic value in glioma management and may serve as a biomarker in neurodegenerative disease assessment.