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GeneE
10 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
MCC
MCC regulator of Wnt signaling pathway
Chromosome 5 Β· 5q22.2
NCBI Gene: 4163Ensembl: ENSG00000171444.19HGNC: HGNC:6935UniProt: P23508
79PubMed Papers
20Diseases
0Drugs
2Pathogenic Variants
FUNCTIONAL ROLE
Tumor Suppressor
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingnucleusnucleoplasmcytosolcolon carcinomaalcohol drinkingjoint diseaseInguinal hernia
✦AI Summary

I cannot provide an accurate gene function summary for MCC (MCC regulator of Wnt signaling pathway) based on the provided abstracts. The PubMed abstracts supplied discuss mucociliary clearance (also abbreviated MCC), Merkel cell carcinoma (also abbreviated MCC), and multiciliated cells (also abbreviated MCC), but contain no information about the MCC gene located on chromosome 5 that functions as a Wnt signaling pathway regulator. The abstracts do not address the gene's role in suppressing cell proliferation, inhibiting Ξ²-catenin/TCF/LEF transcription factors, or its involvement in cell migration and CCAR2-dependent pathway repression. To provide a properly cited summary grounded in PubMed evidence, abstracts specifically examining the MCC gene's molecular function in colorectal cancer and Wnt signaling would be required.

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
colon carcinomaOpen Targets
0.42Moderate
alcohol drinkingOpen Targets
0.24Weak
joint diseaseOpen Targets
0.24Weak
Inguinal herniaOpen Targets
0.22Weak
peripheral nervous system diseaseOpen Targets
0.21Weak
alopeciaOpen Targets
0.21Weak
Breast hypertrophyOpen Targets
0.20Weak
hypertensionOpen Targets
0.17Weak
type 2 diabetes mellitusOpen Targets
0.12Weak
prostate cancerOpen Targets
0.11Weak
Familial prostate cancerOpen Targets
0.11Weak
schizophreniaOpen Targets
0.10Weak
bipolar disorderOpen Targets
0.10Weak
ovarian neoplasmOpen Targets
0.10Weak
major depressive disorderOpen Targets
0.10Suggestive
neoplasmOpen Targets
0.09Suggestive
colorectal cancerOpen Targets
0.08Suggestive
Miyoshi myopathyOpen Targets
0.08Suggestive
glioblastomaOpen Targets
0.08Suggestive
diabetes mellitusOpen Targets
0.07Suggestive
Pathogenic Variants2
NM_001085377.2(MCC):c.2663C>T (p.Ala888Val)Pathogenic
Carcinoma of colon
β˜†β˜†β˜†β˜†1991β†’ Residue 888
NM_001085377.2(MCC):c.2087G>A (p.Arg696Gln)Pathogenic
Carcinoma of colon
β˜†β˜†β˜†β˜†1991β†’ Residue 696
View on ClinVar β†—
Related Genes
HEATR1Protein interaction100%UTP4Protein interaction100%UTP15Protein interaction100%WDR75Protein interaction100%NOP56Protein interaction100%UTP6Protein interaction100%
Tissue Expression6 tissues
Ovary
100%
Heart
27%
Liver
23%
Lung
9%
Brain
5%
Bone Marrow
1%
Gene Interaction Network
Click a node to explore
MCCHEATR1UTP4UTP15WDR75NOP56UTP6
PROTEIN STRUCTURE
Preparing viewer…
PDB6MTU Β· 2.14 Γ… Β· X-ray
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
0.92LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.77 [0.64–0.92]
RankingsWhere MCC stands among ~20K protein-coding genes
  • #6,007of 20,598
    Most Researched79
  • #4,358of 5,498
    Most Pathogenic Variants2
  • #8,411of 17,882
    Most Constrained (LOEUF)0.92
Genes detectedMCC
Sources retrieved10 papers
Response timeβ€”
πŸ“„ Sources
10β–Ό
1
Cilia and Mucociliary Clearance.
PMID: 27864314
Cold Spring Harb Perspect Biol Β· 2017
1.00
2
The significance of PAX5 in Merkel cell carcinoma.
PMID: 40034069
J Pathol Β· 2025
0.90
3
Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread.
PMID: 39488529
Nat Commun Β· 2024
0.80
4
[Human polyomavirus-associated skin diseases].
PMID: 35482045
Hautarzt Β· 2022
0.70
5
Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma.
PMID: 39933141
J Clin Invest Β· 2025
0.60