MEMO1 (mediator of cell motility 1) is an evolutionarily conserved protein that functions as an iron-binding protein involved in cellular redox homeostasis and cancer cell motility 1. The protein binds iron with high affinity under intracellular redox conditions and exhibits structural similarity to iron-containing extradiol dioxygenases 1. MEMO1 modulates iron homeostasis in cancer cells through interactions with iron-related proteins including transferrin receptor 2 (TFR2), mitoferrin-2 (SLC25A28), and iron response regulator IRP1 (ACO1), making cells with high MEMO1 expression hypersensitive to iron distribution disruptions 1. The protein also protects cancer cells from copper-mediated oxidative stress by coordinating reduced copper ions and preventing reactive oxygen species (ROS) generation 2. In cancer contexts, MEMO1 is overexpressed in multiple cancer types and modulates breast cancer metastasis through altered cell motility 3. The protein interacts with phosphorylated ErbB2 through a pH-dependent mechanism that requires phosphorylation for binding 4. Additionally, MEMO1 plays roles in mineralization processes, being required for ameloblast maturation and functional enamel formation 5. HPV16 E7 oncoprotein targets MEMO1 for proteasomal degradation, and MEMO1 reduction correlates with increased cell proliferation and Akt activation in cervical cancer 6.