NUP210 (nucleoporin 210) is a membrane-spanning nuclear pore complex protein that serves essential structural and regulatory functions in cellular nucleocytoplasmic transport and mechanosensing. The protein is critical for nuclear pore assembly, spacing, and structural integrity, facilitating the bidirectional transport of molecules between the nucleus and cytoplasm 1. NUP210 functions as a cellular mechanosensor by interacting with LINC complex protein SUN2, which connects the nucleus to the cytoskeleton, and forms complexes with chr3 regulators including BRD4 and histones at the nuclear periphery 2. The protein requires nuclear localization sequences to properly localize to the nuclear membrane and interact with importin-α/β for nuclear transport regulation 1. Disease relevance includes significant upregulation in multiple cancers, where high NUP210 expression correlates with poor prognosis in acute myeloid leukemia, breast cancer metastasis, colorectal cancer, and cervical cancer 345. In cancer contexts, NUP210 promotes malignant behavior through various mechanisms including regulation of HOXA9 expression in leukemia and modulation of mechanotransduction pathways in metastasis 42. Additionally, NUP210 variants are associated with endometriosis risk and kidney disease susceptibility 67.