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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
NUP62CL
nucleoporin 62 C-terminal like
Chromosome X Β· Xq22.3
NCBI Gene: 54830Ensembl: ENSG00000198088.11HGNC: HGNC:25960UniProt: A0A0S2Z5E8
19PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transporter
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingstructural constituent of nuclear porenucleocytoplasmic transportnuclear envelopealcoholic pancreatitisosteoarthritis, kneeosteoarthritis, hipmedical procedure
✦AI Summary

NUP62CL is a nucleoporin 62 C-terminal-like protein with protein binding capability. Based on limited published evidence, NUP62CL expression correlates with clinical outcomes in lung adenocarcinoma, with low expression associated with improved prognosis 1. High NUP62CL expression significantly predicts worse survival outcomes and correlates with advanced clinical staging 1. Gene set enrichment analysis suggests involvement in telomere recombination and maintenance pathways 1. NUP62CL expression positively correlates with infiltration of B lymphocytes and memory CD4+ T cells in lung adenocarcinoma 1.

Sources cited
1
Low NUP62CL expression indicates good prognosis in lung adenocarcinoma; high expression predicts worse survival and correlates with advanced clinical stage; involvement in telomere maintenance pathways; positive correlation with tumor-infiltrating B lymphocytes and memory CD4+ T cells
PMID: 33934535
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜20
alcoholic pancreatitisOpen Targets
0.20Weak
osteoarthritis, kneeOpen Targets
0.13Weak
osteoarthritis, hipOpen Targets
0.11Weak
medical procedureOpen Targets
0.09Suggestive
oral squamous cell carcinomaOpen Targets
0.08Suggestive
isolated asymptomatic elevation of creatine phosphokinaseOpen Targets
0.06Suggestive
lung adenocarcinomaOpen Targets
0.06Suggestive
pentosuriaOpen Targets
0.04Suggestive
hemolytic anemia due to glutathione reductase deficiencyOpen Targets
0.04Suggestive
neoplasmOpen Targets
0.04Suggestive
Fuchs endothelial corneal dystrophyOpen Targets
0.04Suggestive
granular corneal dystrophy type IOpen Targets
0.04Suggestive
pseudohyperaldosteronism type 2Open Targets
0.04Suggestive
X-linked endothelial corneal dystrophyOpen Targets
0.04Suggestive
lattice corneal dystrophy type IOpen Targets
0.04Suggestive
granular corneal dystrophy type IIOpen Targets
0.03Suggestive
Familial ocular anterior segment mesenchymal dysgenesisOpen Targets
0.03Suggestive
hemolytic anemia due to erythrocyte adenosine deaminase overproductionOpen Targets
0.03Suggestive
cataract - microcornea syndromeOpen Targets
0.03Suggestive
Cataract-microcornea syndromeOpen Targets
0.03Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
NUP210Shared pathway100%NUP43Shared pathway100%NUP37Shared pathway100%NUP133Protein interaction100%NUP98Protein interaction100%NUP88Protein interaction86%
Tissue Expression6 tissues
Bone Marrow
100%
Liver
17%
Heart
14%
Brain
8%
Ovary
6%
Lung
4%
Gene Interaction Network
Click a node to explore
NUP62CLNUP210NUP43NUP37NUP133NUP98NUP88
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q9H1M0
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.35LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.85 [0.55–1.35]
RankingsWhere NUP62CL stands among ~20K protein-coding genes
  • #14,483of 20,598
    Most Researched19
  • #14,158of 17,882
    Most Constrained (LOEUF)1.35
Genes detectedNUP62CL
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
The low expression of NUP62CL indicates good prognosis and high level of immune infiltration in lung adenocarcinoma.
PMID: 33934535
Cancer Med Β· 2021
1.00