PAK4 is a serine/threonine kinase that regulates multiple cellular processes including cell migration, survival, and metabolism. PAK4 promotes cancer progression by enhancing tumor cell migration, invasion, and epithelial-mesenchymal transition 1. In colorectal cancer, PAK4 is part of an immune exclusion signature associated with reduced cytotoxic cell infiltration and poor prognosis 2. The kinase also plays a critical role in metabolic regulation by phosphorylating NCoR1, which suppresses fatty acid β-oxidation and ketogenesis through enhanced PPARα repression 3. In glioblastoma, PAK4 is released from migrasomes to promote cell migration and invasion 4. PAK4 contributes to kidney injury by phosphorylating and inactivating glutathione peroxidase 3, leading to increased oxidative stress and impaired fatty acid metabolism 5. The kinase functions through a PAK4-CREB transcriptional axis that regulates diverse cellular programs 6. PAK4 is frequently overexpressed in various cancers, making it an attractive therapeutic target 7. Its dysregulation contributes to pathological conditions by altering cell adhesion, proliferation, and survival pathways.