Based on limited published evidence, RNF103-CHMP3 readthrough is a readthrough transcript fusion gene located on chromosome 2. Database annotations suggest functional roles in ESCRT-mediated protein sorting and vesicular transport (typical of CHMP3 component). Recent research identifies RNF103-CHMP3 as a key gene associated with diabetic foot ulcers, linked to extracellular interactions and tissue repair mechanisms 1. The gene shows significant downregulation in successfully healed diabetic foot ulcer patients, particularly in NK cells and macrophages 1, suggesting involvement in wound healing and cellular communication.