RSU1 (Ras suppressor protein 1) is a focal adhesion protein that functions as a negative regulator of Ras signaling and F-actin dynamics. RSU1 localizes to focal adhesions through interaction with PINCH1, a component of the ILK/PINCH/Parvin (IPP) complex 1. Structurally, RSU1's leucine-rich repeats form a solenoid that binds PINCH1's C-terminal region, blocking IPP-mediated F-actin bundling and impairing stress fiber formation 1. RSU1 connects the IPP complex to PTEN transcription through ATF2 activation and p38 MAP kinase signaling 2. Clinically, RSU1 shows tumor-suppressive properties across multiple cancer types. Expression is downregulated in lung adenocarcinoma and hepatocellular carcinoma, correlating with poor prognosis 34. RSU1 depletion promotes anchorage-independent growth, cell motility, and epithelial-mesenchymal transition in lung cancer cells 3. RSU1 is also dysregulated in neurodegenerative and cardiovascular diseases: it appears as an upregulated biomarker in Alzheimer's disease plasma exosomes 5 and is implicated in hypertension mechanisms through modulation of nitrogen metabolism pathways 6. Additionally, RSU1 levels serve as a stroke recurrence predictor in ischemic stroke patients 7. MicroRNAs (miR-182-5p, -409-3p, -130a-3p, -221-3p) post-transcriptionally regulate RSU1 expression in breast cancer 2.