SNTB1 (syntrophin beta 1) is an adapter protein that organizes subcellular localization of membrane proteins and links receptors to the actin cytoskeleton and dystrophin glycoprotein complex 1. Beyond its established role in neuromuscular junction organization, SNTB1 has emerged as a significant susceptibility gene for high myopia across multiple populations. Specific SNTB1 polymorphisms (rs7839488, rs4395927, rs4455882, rs6469937) are associated with myopia risk, with certain variants conferring protective effects and others increasing susceptibility 234. The G-C-A-G haplotype is identified as a risk haplotype for high myopia in Northern Han Chinese populations 1. Beyond ocular development, SNTB1 plays a critical role in cancer progression. In colorectal adenocarcinoma, SNTB1 overexpression promotes metastasis through SRC-mediated activation of the Hippo-YAP pathway, facilitating epithelial-mesenchymal transition (EMT) 56. Similarly, in gastric cancer, ZC3H13-mediated N6-methyladenosine modification of SNTB1 promotes EMT and cancer progression 7. These findings establish SNTB1 as both an important genetic determinant of myopia susceptibility and a potential oncogenic driver in gastrointestinal malignancies.