TEX12 is a component of the synaptonemal complex (SC) central element that plays essential roles in meiotic chromosome 11 and male fertility 1. TEX12 forms a highly stable hetero-octameric complex with SYCE2, consisting of an SYCE2 tetramer and two TEX12 dimers that spontaneously assemble into filamentous structures resembling the SC central element 1. This SYCE2-TEX12 complex exhibits hierarchical fibrous assembly through coiled-coil interactions, forming 10-nm fibers that bundle into 40-nm micrometer-long fibers defining the SC's midline structure, similar to cytoskeletal intermediate filament proteins 2. Beyond its meiotic function, TEX12 also localizes to centrosomes during meiosis independently of chromosome 11 3. Loss-of-function mutations in TEX12 cause male infertility, as demonstrated by a homozygous 5-bp deletion resulting in premature truncation that caused nonobstructive azoospermia in two brothers 4. Additionally, TEX12 expression is significantly downregulated in patients with spermatogenic failure, suggesting its critical role in early spermatogenesis 5. When aberrantly expressed in somatic cells, TEX12 functions as a cancer-testis antigen and contributes to pathological centrosome amplification, a hallmark of cancer development 3.