TUBA1A encodes a neural-specific alpha-tubulin isoform that serves as a fundamental structural component of microtubules in the developing nervous system 1. As part of the tubulin heterodimer complex, TUBA1A contributes to microtubule dynamics essential for neuronal migration, axon guidance, and cortical development 2. The protein's expression is restricted to developing and regenerating nervous tissue, where it plays critical roles in neuronal migration during corticogenesis 12. Mutations in TUBA1A cause tubulinopathies, a group of neurodevelopmental disorders characterized by severe brain malformations including lissencephaly, microcephaly, and abnormal cortical development 32. These mutations typically alter microtubule dynamics by affecting GTP binding, protofilament interactions, or interactions with motor proteins and microtubule-associated proteins 2. TUBA1A variants are predominantly de novo and cause autosomal dominant disorders with highly variable phenotypes ranging from severe lissencephaly to milder dysgyria patterns 34. The gene has also been implicated in cerebral palsy risk, with damaging mutations contributing to dysregulated neuronal connectivity 5. Additionally, TUBA1A shows altered ubiquitination patterns in hepatocellular carcinoma, suggesting broader cellular roles beyond neurodevelopment 6.