TUBA4B is a long non-coding RNA (lncRNA), not a protein-coding gene as suggested by its name association with tubulin alpha 4b. Functionally, TUBA4B acts as a tumor suppressor across multiple cancer types through competitive endogenous RNA (ceRNA) mechanisms. In colorectal cancer, low TUBA4B expression promotes proliferation and inhibits apoptosis by reducing p15 and p16 expression 1. In gastric cancer, TUBA4B functions as a ceRNA that sequesters miR-214 and miR-216a/b to increase PTEN expression, thereby inactivating PI3K/AKT signaling 2. Similarly, in breast cancer, TUBA4B suppresses proliferation and invasion by directly targeting miR-19 3. In ovarian cancer, TUBA4B overexpression reduces proliferation and attenuates ERK and Akt signaling activation 4. Clinically, TUBA4B is significantly downregulated in multiple cancer tissues including lung, colorectal, breast, and ovarian cancers 5. Low TUBA4B expression correlates with poor overall survival, disease-free survival, and recurrence-free survival across various cancers, making it a valuable prognostic biomarker 5. Additionally, TUBA4B hypermethylation is associated with poor prognosis in posterior fossa ependymoma 6. These findings suggest TUBA4B reactivation represents a promising therapeutic target for cancer treatment.