VPS4A (vacuolar protein sorting 4 homolog A) is an AAA+ ATPase that serves multiple critical cellular functions through its role in membrane fission processes. The protein functions as a selective receptor for lipophagy, where phosphorylation at Ser95,97 drives its localization to lipid droplets during fasting, mediating their degradation in lysosomes in an autophagy-dependent manner 1. VPS4A also plays a unique regulatory role in cytokinetic abscission, distinct from its paralog VPS4B, by binding abscission checkpoint proteins CHMP4C and ANCHR and functioning in earlier stages of cell division 2. As part of the ESCRT machinery, VPS4A mediates phagophore closure during autophagy processes, including virus-induced mitophagy where it is recruited by viral proteins to facilitate mitochondrial clearance 3. The protein has been identified as a therapeutic target, as compounds like aloperine can bind VPS4A (at residues F153 and D263) to inhibit autophagosome-lysosome fusion, leading to cancer cell apoptosis 4. Clinically, de novo mutations in VPS4A have been associated with intellectual disability, highlighting its importance in neurodevelopment 5. VPS4A levels are reduced in human steatotic livers, indicating its significance in metabolic liver diseases 1.