ZNF207 is a multifunctional zinc finger protein with roles spanning cell division, stem cell biology, and cancer progression. Canonically, ZNF207 functions as a kinetochore- and microtubule-binding protein essential for spindle assembly 12. ZNF207 contains low-complexity disordered regions that undergo phase transition to form liquid droplets, concentrating tubulin and promoting microtubule polymerization and spindle matrix assembly 3. It stabilizes the checkpoint protein BUB3 at kinetochores, though the precise mechanism remains unclear 12. Beyond mitosis, a distinct ZNF207 isoform regulates self-renewal and pluripotency in human embryonic stem cells by partnering with OCT4, SOX2, and NANOG, while simultaneously controlling neuronal differentiation 4. In cancer, ZNF207 exhibits oncogenic properties across multiple tumor types, particularly hepatocellular carcinoma (HCC). It promotes HCC progression by transcriptionally activating glycolytic enzymes ENO1 and GAPDH to enhance aerobic glycolysis 5, and drives regorafenib resistance through ZNF207-mediated PRDX1 lactylation and NRF2 activation, suppressing ferroptosis 6. ZNF207 also functions as an immunosuppressive factor, reducing CD8+ T-cell infiltration and promoting exhaustion via MAPK-chemokine signaling and IDO1-mediated kynurenine production 7. Recent evidence reveals unexpected involvement in LMNA splicing regulation, where ZNF207 interacts with U1 snRNP components to modulate alternative splicing, including progerin production in progeria 8. ZNF207 emerges as a pan-cancer prognostic biomarker and therapeutic target 910.