ZNF574 is a zinc finger protein that functions as a key quality control factor in ribosome biogenesis, serving as a component of the Ribosome Assembly Surveillance Pathway (RASP) 12. ZNF574 monitors eukaryotic ribosome assembly intermediates and specifically recognizes defective or "dead-end" intermediates, targeting them for degradation via the ubiquitin-proteasome system 12. This quality control mechanism is essential for maintaining protein homeostasis and organismal health, as loss of ZNF574 results in accumulation of faulty biogenesis intermediates that impair global ribosome production and causes developmental defects 12. Beyond its ribosome quality control function, ZNF574 exhibits oncogenic activity in certain cancers. In ovarian cancer, ZNF574 is upregulated and promotes cell proliferation and migration through regulation of AKT and AMPK signaling pathways; elevated expression correlates with poor prognosis 3. ZNF574 knockdown inhibits cancer cell growth, promotes apoptosis, and enhances chemosensitivity to cisplatin 3. Additionally, ZNF574 was identified as a candidate susceptibility locus in early-onset colorectal cancer and exhibits epigenetic dysregulation during human embryonic stem cell differentiation 45.