KIF16B is a plus-end-directed microtubule motor protein belonging to the kinesin-3 family that plays crucial roles in intracellular transport and endosomal trafficking 1. The protein contains a characteristic PX domain that binds phosphatidylinositol-3-phosphate (PI(3)P) and facilitates membrane association, enabling transport of intracellular cargo and formation of endosomal tubules 1. KIF16B mediates anterograde transport by directing outward movement of Rab14-positive vesicles from internal compartments toward the plasma membrane 2. The protein regulates receptor recycling and degradation pathways, particularly for growth factor receptors, and prevents lysosomal degradation by promoting efficient trafficking to the cell surface 2. KIF16B drives fast recycling of matrix metalloproteinase MT1-MMP to macrophage surfaces, supporting matrix degradation and cellular invasion 3. Additionally, KIF16B mediates transcytosis of basolateral proteins to the apical membrane in epithelial cells lacking AP-1B, working in conjunction with galectin-4 for proper sorting 4. Clinical studies have identified KIF16B genetic variants associated with nonsmall cell lung cancer survival and small intestinal neuroendocrine tumor risk, suggesting potential therapeutic relevance 56.