TEX15 (testis expressed 15) is a meiosis-specific gene critical for male fertility that functions primarily in DNA double-strand break repair during spermatogenesis 1. The protein mediates homologous recombination repair mechanisms essential for proper crossover formation and chromosome 8 during meiotic prophase I 12. TEX15 is specifically expressed in testicular germ cells and is required for synaptonemal complex assembly, with its expression being essential for early stages of spermatogenesis 3. Loss-of-function mutations in TEX15 cause severe spermatogenic failure ranging from oligozoospermia to nonobstructive azoospermia with meiotic arrest 14. Recessive TEX15 mutations have been identified in approximately 0.6% of male infertility patients, with compound heterozygous variants causing varying degrees of spermatogenic failure 1. The gene shows significant down-regulation in patients with sertoli cell-only syndrome compared to controls 3. Additionally, certain polymorphisms in TEX15 confer susceptibility to spermatogenic failure in some populations 5. Interestingly, rare variants in TEX15 have also been associated with prostate cancer risk, suggesting broader roles in DNA repair beyond meiosis 6.