WDR12 (WD repeat domain 12) is a component of the PeBoW complex essential for ribosomal RNA processing and ribosome biogenesis 1. As a WD-repeat protein, WDR12 functions in the maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosomal subunit, with the complex controlling nucleolar localization and pre-ribosome association 1. Beyond its canonical ribosomal function, WDR12 has emerged as a key player in multiple disease contexts. Mutations in WDR12 cause tapered sperm head morphology, contributing to male infertility and teratozoospermia 2. In cardiovascular disease, WDR12 is implicated in lacunar stroke pathogenesis, with genetic associations identified in genome-wide studies involving 7,338 cases and 254,798 controls 3. In cancer biology, WDR12 functions as an oncogene across multiple malignancies. In colorectal cancer, WDR12 is highly expressed and promotes tumor progression through the WDR12/RAC1 axis, enhancing proliferation and inhibiting apoptosis 4. Similarly, in glioblastoma, elevated WDR12 expression correlates with reduced survival and promotes proliferation through cell cycle regulation involving PLK1 and EZH2 5. Pan-cancer analysis demonstrates WDR12 as a prognostic biomarker with expression patterns correlating with immune infiltration and tumor mutation burden 6. Additionally, WDR12 participates in myocardial ischemia-reperfusion injury through the circMIRIAF/miR-544/WDR12 axis, regulating oxidative stress and inflammation via Notch1 signaling 7.