Most Researched

Genes ranked by total PubMed publication count — the most-studied genes in biology.

Filter by chromosome
151200 of 20,598 genesranked by Most Researched
#GeneNameChrTagsPubMed Papers
151SMAD3SMAD family member 315Transcription FactorOMIM Disease Gene
1,028
152AGERadvanced glycosylation end-product specific receptor6DNA RepairReceptor
1,026
153MKI67marker of proliferation Ki-6710Highly StudiedExperimental GO Evidence
1,023
154APCAPC regulator of Wnt signaling pathway5Highly ConstrainedTumor Suppressor
1,021
155MMP1matrix metallopeptidase 111ProteaseFDA Approved Target
1,020
156CREBBPCREB binding lysine acetyltransferase16Highly ConstrainedClinical Trials
1,012
157IL1Ainterleukin 1 alpha2FDA Approved TargetHighly Studied
1,009
158HFEhomeostatic iron regulator6TransporterOMIM Disease Gene
1,001
159NOD2nucleotide binding oligomerization domain containing 216FDA Approved TargetOMIM Disease Gene
1,001
160AGTR1angiotensin II receptor type 13ReceptorFDA Approved Target
997
161RETret proto-oncogene10Highly ConstrainedKinase
995
162PCNAproliferating cell nuclear antigen20DNA RepairOMIM Disease Gene
991
163HSPA8heat shock protein family A (Hsp70) member 811Highly ConstrainedClinical Trials
990
164PRKNparkin RBR E3 ubiquitin protein ligase6OMIM Disease GeneHighly Studied
989
165SOD2superoxide dismutase 26OMIM Disease GeneHighly Studied
985
166IDH1isocitrate dehydrogenase (NADP(+)) 12FDA Approved TargetOMIM Disease Gene
984
167CASP8caspase 82ApoptosisProtease
980
168HLA-Gmajor histocompatibility complex, class I, G6Highly StudiedExperimental GO Evidence
980
169PRKCAprotein kinase C alpha17KinaseOncogene
978
170CYP2C9cytochrome P450 family 2 subfamily C member 910Highly StudiedExperimental GO Evidence
971
171E2F1E2F transcription factor 120Transcription FactorClinical Trials
969
172CYP3A4cytochrome P450 family 3 subfamily A member 47FDA Approved TargetOMIM Disease Gene
965
173TP63tumor protein p633Highly ConstrainedTranscription Factor
965
174MUC1mucin 1, cell surface associated1Tumor SuppressorClinical Trials
960
175APOBapolipoprotein B2TransporterFDA Approved Target
954
176GRB2growth factor receptor bound protein 217Highly ConstrainedClinical Trials
953
177VIMvimentin10Clinical TrialsOMIM Disease Gene
949
178ABCG2ATP binding cassette subfamily G member 2 (JR blood group)4TransporterHighly Studied
944
179HSPA4heat shock protein family A (Hsp70) member 45Highly ConstrainedHighly Studied
944
180PTPN11protein tyrosine phosphatase non-receptor type 1112Highly ConstrainedClinical Trials
943
181MSH2mutS homolog 22DNA RepairTumor Suppressor
937
182CSNK2A1casein kinase 2 alpha 120Highly ConstrainedKinase
936
183RUNX1RUNX family transcription factor 121OncogeneOMIM Disease Gene
935
184CDK2cyclin dependent kinase 212DNA RepairKinase
930
185TNFSF10TNF superfamily member 103Highly StudiedExperimental GO Evidence
928
186EDN1endothelin 16OMIM Disease GeneHighly Studied
927
187PLK1polo like kinase 116Highly ConstrainedKinase
927
188FMR1fragile X messenger ribonucleoprotein 1XDNA RepairTransporter
923
189ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit19ApoptosisDNA Repair
921
190GHRLghrelin and obestatin prepropeptide3Highly StudiedExperimental GO Evidence
920
191VHLvon Hippel-Lindau tumor suppressor3Tumor SuppressorOMIM Disease Gene
919
192ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase9DNA RepairHighly Constrained
918
193SMAD4SMAD family member 418Highly ConstrainedTranscription Factor
915
194PRKDCprotein kinase, DNA-activated, catalytic subunit8DNA RepairHighly Constrained
913
195IL2interleukin 24OncogeneHighly Studied
900
196LCN2lipocalin 29TransporterHighly Studied
896
197LDLRlow density lipoprotein receptor19ReceptorTransporter
893
198MIFmacrophage migration inhibitory factor22OMIM Disease GeneHighly Studied
891
199CFHcomplement factor H1OMIM Disease GeneHighly Studied
890
200DNMT1DNA methyltransferase 119Highly ConstrainedFDA Approved Target
879