Most Researched

Genes ranked by total PubMed publication count — the most-studied genes in biology.

Filter by chromosome
Showing 151200 of 20,598 genes
#GeneNameChrTagsPubMedPubMed Papers
151SMAD3SMAD family member 315Hub GeneTranscription Factor1,0281,028
152AGERadvanced glycosylation end-product specific receptor6DNA RepairReceptor1,0261,026
153MKI67marker of proliferation Ki-6710Hub GeneHighly Studied1,0231,023
154APCAPC regulator of Wnt signaling pathway5Highly ConstrainedHub Gene1,0211,021
155MMP1matrix metallopeptidase 111ProteaseFDA Approved Target1,0201,020
156CREBBPCREB binding lysine acetyltransferase16Highly ConstrainedHub Gene1,0121,012
157IL1Ainterleukin 1 alpha2Hub GeneFDA Approved Target1,0091,009
158HFEhomeostatic iron regulator6TransporterOMIM Disease Gene1,0011,001
159NOD2nucleotide binding oligomerization domain containing 216Hub GeneFDA Approved Target1,0011,001
160AGTR1angiotensin II receptor type 13ReceptorFDA Approved Target997997
161RETret proto-oncogene10Highly ConstrainedHub Gene995995
162PCNAproliferating cell nuclear antigen20DNA RepairHub Gene991991
163HSPA8heat shock protein family A (Hsp70) member 811Highly ConstrainedHub Gene990990
164PRKNparkin RBR E3 ubiquitin protein ligase6Hub GeneTranscription Factor989989
165SOD2superoxide dismutase 26Hub GeneOMIM Disease Gene985985
166IDH1isocitrate dehydrogenase (NADP(+)) 12Hub GeneFDA Approved Target984984
167CASP8caspase 82ApoptosisHub Gene980980
168HLA-Gmajor histocompatibility complex, class I, G6Highly StudiedExperimental GO Evidence980980
169PRKCAprotein kinase C alpha17Hub GeneKinase978978
170CYP2C9cytochrome P450 family 2 subfamily C member 910Hub GeneHighly Studied971971
171E2F1E2F transcription factor 120Hub GeneTranscription Factor969969
172CYP3A4cytochrome P450 family 3 subfamily A member 47Hub GeneFDA Approved Target965965
173TP63tumor protein p633Highly ConstrainedTranscription Factor965965
174MUC1mucin 1, cell surface associated1Hub GeneTumor Suppressor960960
175APOBapolipoprotein B2Hub GeneTransporter954954
176GRB2growth factor receptor bound protein 217Highly ConstrainedHub Gene953953
177VIMvimentin10Clinical TrialsOMIM Disease Gene949949
178ABCG2ATP binding cassette subfamily G member 2 (JR blood group)4TransporterHighly Studied944944
179HSPA4heat shock protein family A (Hsp70) member 45Highly ConstrainedHub Gene944944
180PTPN11protein tyrosine phosphatase non-receptor type 1112Highly ConstrainedHub Gene943943
181MSH2mutS homolog 22DNA RepairHub Gene937937
182CSNK2A1casein kinase 2 alpha 120Highly ConstrainedKinase936936
183RUNX1RUNX family transcription factor 121Hub GeneOncogene935935
184CDK2cyclin dependent kinase 212DNA RepairHub Gene930930
185TNFSF10TNF superfamily member 103Highly StudiedExperimental GO Evidence928928
186EDN1endothelin 16Hub GeneOMIM Disease Gene927927
187PLK1polo like kinase 116Highly ConstrainedHub Gene927927
188FMR1fragile X messenger ribonucleoprotein 1XDNA RepairHub Gene923923
189ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit19ApoptosisDNA Repair921921
190GHRLghrelin and obestatin prepropeptide3Hub GeneHighly Studied920920
191VHLvon Hippel-Lindau tumor suppressor3Hub GeneTumor Suppressor919919
192ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase9DNA RepairHighly Constrained918918
193SMAD4SMAD family member 418Highly ConstrainedHub Gene915915
194PRKDCprotein kinase, DNA-activated, catalytic subunit8DNA RepairHighly Constrained913913
195IL2interleukin 24Hub GeneOncogene900900
196LCN2lipocalin 29TransporterHighly Studied896896
197LDLRlow density lipoprotein receptor19ReceptorTransporter893893
198MIFmacrophage migration inhibitory factor22OMIM Disease GeneHighly Studied891891
199CFHcomplement factor H1OMIM Disease GeneHighly Studied890890
200DNMT1DNA methyltransferase 119Highly ConstrainedHub Gene879879