Most Researched

Genes ranked by total PubMed publication count — the most-studied genes in biology.

Filter by chromosome
101150 of 20,598 genesranked by Most Researched
#GeneNameChrTagsPubMed Papers
101RAC1Rac family small GTPase 17Highly ConstrainedOMIM Disease Gene
1,340
102CTLA4cytotoxic T-lymphocyte associated protein 42Highly ConstrainedFDA Approved Target
1,338
103HDAC1histone deacetylase 11FDA Approved TargetHighly Studied
1,335
104SOD1superoxide dismutase 121FDA Approved TargetOMIM Disease Gene
1,328
105JUNJun proto-oncogene, AP-1 transcription factor subunit1OncogeneTranscription Factor
1,326
106DRD2dopamine receptor D211ReceptorFDA Approved Target
1,325
107IL4interleukin 45Clinical TrialsOMIM Disease Gene
1,301
108NLRP3NLR family pyrin domain containing 31OMIM Disease GeneHighly Studied
1,292
109NR3C1nuclear receptor subfamily 3 group C member 15Highly ConstrainedReceptor
1,291
110PON1paraoxonase 17OMIM Disease GeneHighly Studied
1,282
111ESR2estrogen receptor 214ReceptorFDA Approved Target
1,277
112IGF1Rinsulin like growth factor 1 receptor15KinaseReceptor
1,269
113FASFas cell surface death receptor10ApoptosisReceptor
1,259
114CASP3caspase 34ApoptosisProtease
1,254
115PDCD1programmed cell death 12OMIM Disease GeneHighly Studied
1,253
116CAV1caveolin 17OMIM Disease GeneHighly Studied
1,228
117ITGB3integrin subunit beta 317ReceptorFDA Approved Target
1,223
118CDK1cyclin dependent kinase 110KinaseReceptor
1,209
119HMOX1heme oxygenase 122OMIM Disease GeneHighly Studied
1,204
120SPP1secreted phosphoprotein 14Clinical TrialsHighly Studied
1,203
121IL18interleukin 1811Clinical TrialsHighly Studied
1,189
122KITKIT proto-oncogene, receptor tyrosine kinase4Highly ConstrainedKinase
1,173
123FOXP3forkhead box P3XHighly ConstrainedTranscription Factor
1,170
124NPM1nucleophosmin 15DNA RepairHighly Constrained
1,170
125RHOAras homolog family member A3OncogeneOMIM Disease Gene
1,169
126HSPA5heat shock protein family A (Hsp70) member 59Highly StudiedExperimental GO Evidence
1,168
127AGTangiotensinogen1Clinical TrialsOMIM Disease Gene
1,161
128STAT1signal transducer and activator of transcription 12Highly ConstrainedTranscription Factor
1,153
129NPPBnatriuretic peptide B1Highly StudiedExperimental GO Evidence
1,148
130ADRB2adrenoceptor beta 25ReceptorFDA Approved Target
1,129
131APOA1apolipoprotein A111TransporterOMIM Disease Gene
1,127
132BAXBCL2 associated X, apoptosis regulator19ApoptosisTumor Suppressor
1,121
133CYP1A1cytochrome P450 family 1 subfamily A member 115Highly StudiedExperimental GO Evidence
1,117
134CYP2C19cytochrome P450 family 2 subfamily C member 1910Highly StudiedExperimental GO Evidence
1,111
135HLA-Cmajor histocompatibility complex, class I, C6OMIM Disease GeneHighly Studied
1,109
136MLH1mutL homolog 13DNA RepairTumor Suppressor
1,109
137CDKN1Bcyclin dependent kinase inhibitor 1B12Tumor SuppressorOMIM Disease Gene
1,107
138LRRK2leucine rich repeat kinase 212KinaseOMIM Disease Gene
1,107
139KDRkinase insert domain receptor4Highly ConstrainedKinase
1,104
140TARDBPTAR DNA binding protein1Highly ConstrainedOMIM Disease Gene
1,097
141PTK2protein tyrosine kinase 28KinaseClinical Trials
1,096
142CYP2D6cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)22Highly StudiedExperimental GO Evidence
1,089
143LMNAlamin A/C1OMIM Disease GeneHighly Studied
1,085
144LGALS3galectin 314Clinical TrialsHighly Studied
1,064
145SQSTM1sequestosome 15OMIM Disease GeneHighly Studied
1,058
146MAPK8mitogen-activated protein kinase 810KinaseClinical Trials
1,055
147FTOFTO alpha-ketoglutarate dependent dioxygenase16Clinical TrialsOMIM Disease Gene
1,051
148IL1RNinterleukin 1 receptor antagonist2OMIM Disease GeneHighly Studied
1,050
149INSinsulin11OMIM Disease GeneHighly Studied
1,033
150VWFvon Willebrand factor12FDA Approved TargetOMIM Disease Gene
1,033