Most Researched

Genes ranked by total PubMed publication count — the most-studied genes in biology.

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1,9512,000 of 20,598 genesranked by Most Researched
#GeneNameChrTagsPubMed Papers
1951PADI4peptidyl arginine deiminase 41OMIM Disease GeneExperimental GO Evidence
213
1952RELREL proto-oncogene, NF-kB subunit2OncogeneOMIM Disease Gene
213
1953RFC3replication factor C subunit 313DNA RepairExperimental GO Evidence
213
1954RRM2ribonucleotide reductase regulatory subunit M22DNA RepairHighly Constrained
213
1955SPRY2sprouty RTK signaling antagonist 213OMIM Disease GeneExperimental GO Evidence
213
1956THRAthyroid hormone receptor alpha17ReceptorTranscription Factor
213
1957COL7A1collagen type VII alpha 1 chain3FDA Approved TargetOMIM Disease Gene
212
1958DSTdystonin6Highly ConstrainedOMIM Disease Gene
212
1959FHfumarate hydratase1DNA RepairTumor Suppressor
212
1960GAAalpha glucosidase17FDA Approved TargetOMIM Disease Gene
212
1961GADD45Agrowth arrest and DNA damage inducible alpha1TrendingExperimental GO Evidence
212
1962HLA-DRB5major histocompatibility complex, class II, DR beta 56Clinical TrialsExperimental GO Evidence
212
1963MAOBmonoamine oxidase BXFDA Approved TargetTrending
212
1964MAP2K4mitogen-activated protein kinase kinase 417Highly ConstrainedKinase
212
1965PAX5paired box 59OncogeneOMIM Disease Gene
212
1966RIPK2receptor interacting serine/threonine kinase 28ApoptosisKinase
212
1967RPS15ribosomal protein S1519FDA Approved TargetExperimental GO Evidence
212
1968SART3spliceosome associated factor 3, U4/U6 recycling protein12Experimental GO EvidenceSwiss-Prot Reviewed
212
1969SLC25A11solute carrier family 25 member 1117TransporterOMIM Disease Gene
212
1970SMURF2SMAD specific E3 ubiquitin protein ligase 217Experimental GO EvidenceSwiss-Prot Reviewed
212
1971TUBB6tubulin beta 6 class V18FDA Approved TargetOMIM Disease Gene
212
1972UBR4ubiquitin protein ligase E3 component n-recognin 41Highly ConstrainedOMIM Disease Gene
212
1973APOBEC3Fapolipoprotein B mRNA editing enzyme catalytic subunit 3F22Experimental GO EvidenceSwiss-Prot Reviewed
211
1974CHD7chromodomain helicase DNA binding protein 78Highly ConstrainedOMIM Disease Gene
211
1975FAF2Fas associated factor family member 25Highly ConstrainedExperimental GO Evidence
211
1976FANCIFA complementation group I15DNA RepairOMIM Disease Gene
211
1977HBEGFheparin binding EGF like growth factor5ReceptorEarly Pipeline
211
1978MTREXMtr4 exosome RNA helicase5Experimental GO EvidenceSwiss-Prot Reviewed
211
1979PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 310KinaseTrending
211
1980PNNpinin, desmosome associated protein14Tumor SuppressorExperimental GO Evidence
211
1981PSMB3proteasome 20S subunit beta 317FDA Approved TargetExperimental GO Evidence
211
1982SEC61A1SEC61 translocon subunit alpha 13TransporterOMIM Disease Gene
211
1983TGthyroglobulin8OMIM Disease GeneVariant-Rich
211
1984AKR1C3aldo-keto reductase family 1 member C310Experimental GO EvidenceSwiss-Prot Reviewed
210
1985CCR6C-C motif chemokine receptor 66ReceptorExperimental GO Evidence
210
1986H2AC20H2A clustered histone 201Experimental GO EvidenceSwiss-Prot Reviewed
210
1987HSD17B4hydroxysteroid 17-beta dehydrogenase 45OMIM Disease GeneVariant-Rich
210
1988LARS1leucyl-tRNA synthetase 15OMIM Disease GeneExperimental GO Evidence
210
1989PLD1phospholipase D13OMIM Disease GeneExperimental GO Evidence
210
1990PRDM1PR/SET domain 16Highly ConstrainedTranscription Factor
210
1991RALYRALY heterogeneous nuclear ribonucleoprotein20Experimental GO EvidenceSwiss-Prot Reviewed
210
1992USP8ubiquitin specific peptidase 815Highly ConstrainedProtease
210
1993ACIN1apoptotic chromatin condensation inducer 114Highly ConstrainedExperimental GO Evidence
209
1994AIPAHR interacting HSP90 co-chaperone11OMIM Disease GeneVariant-Rich
209
1995CCR3C-C motif chemokine receptor 33ReceptorExperimental GO Evidence
209
1996HTRA2HtrA serine peptidase 22ProteaseOMIM Disease Gene
209
1997IFNAR1interferon alpha and beta receptor subunit 121ReceptorFDA Approved Target
209
1998LATS2large tumor suppressor kinase 213KinaseTumor Suppressor
209
1999LIMA1LIM domain and actin binding 112Experimental GO EvidenceSwiss-Prot Reviewed
209
2000LONP1lon peptidase 1, mitochondrial19ProteaseOMIM Disease Gene
209