Most Researched

Genes ranked by total PubMed publication count — the most-studied genes in biology.

Filter by chromosome
Showing 501550 of 20,598 genes
#GeneNameChrTagsPubMedPubMed Papers
501TIMP2TIMP metallopeptidase inhibitor 217Highly StudiedTrending522522
502XRCC3X-ray repair cross complementing 314DNA RepairHomologous Recombination520520
503HDAC6histone deacetylase 6XHighly ConstrainedHub Gene519519
504RASSF1Ras association domain family member 13Tumor SuppressorHighly Studied519519
505PPP2CAprotein phosphatase 2 catalytic subunit alpha5Highly ConstrainedHub Gene518518
506BCL2L11BCL2 like 112Highly StudiedExperimental GO Evidence517517
507IL6Rinterleukin 6 receptor1Hub GeneReceptor517517
508BRD4bromodomain containing 419Highly ConstrainedHub Gene516516
509TUBBtubulin beta class I6Highly ConstrainedHub Gene516516
510GATA3GATA binding protein 310Hub GeneTranscription Factor515515
511IDH2isocitrate dehydrogenase (NADP(+)) 215Hub GeneFDA Approved Target515515
512RXRAretinoid X receptor alpha9Highly ConstrainedHub Gene515515
513IDO1indoleamine 2,3-dioxygenase 18Hub GeneFDA Approved Target514514
514LPAlipoprotein(a)6ProteaseTransporter514514
515BMP4bone morphogenetic protein 414Highly ConstrainedHub Gene513513
516EIF4Eeukaryotic translation initiation factor 4E4Highly ConstrainedHub Gene513513
517MMP7matrix metallopeptidase 711ProteaseFDA Approved Target513513
518CYP1A2cytochrome P450 family 1 subfamily A member 215Hub GeneHighly Studied511511
519MYCNMYCN proto-oncogene, bHLH transcription factor2Highly ConstrainedOncogene511511
520PINK1PTEN induced kinase 11Hub GeneKinase510510
521SRSF1serine and arginine rich splicing factor 117Highly ConstrainedHub Gene510510
522HDAC3histone deacetylase 35Hub GeneTranscription Factor509509
523NOTCH3notch receptor 319ReceptorTranscription Factor508508
524STING1stimulator of interferon response cGAMP interactor 15Ion ChannelTransporter508508
525ANXA1annexin A19Highly StudiedTrending507507
526EWSR1EWS RNA binding protein 122Highly ConstrainedHub Gene507507
527IL15interleukin 154Hub GeneClinical Trials506506
528S100BS100 calcium binding protein B21Highly StudiedExperimental GO Evidence506506
529YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta20Highly ConstrainedHub Gene505505
530BCRBCR activator of RhoGEF and GTPase22KinaseOncogene502502
531TNFSF13BTNF superfamily member 13b13FDA Approved TargetHighly Studied502502
532IGF2BP3insulin like growth factor 2 mRNA binding protein 37Highly ConstrainedTransporter501501
533ITGA5integrin subunit alpha 512Hub GeneReceptor501501
534CFL1cofilin 111Hub GeneHighly Studied499499
535PTBP1polypyrimidine tract binding protein 119Highly ConstrainedHub Gene499499
536VEGFCvascular endothelial growth factor C4Clinical TrialsOMIM Disease Gene497497
537ARID1AAT-rich interaction domain 1A1Highly ConstrainedHub Gene494494
538MC4Rmelanocortin 4 receptor18ReceptorFDA Approved Target494494
539PTX3pentraxin 33Highly StudiedTrending494494
540DNMT3BDNA methyltransferase 3 beta20Hub GeneOMIM Disease Gene492492
541FCGR3AFc gamma receptor IIIa1Hub GeneReceptor492492
542ERGETS transcription factor ERG21Highly ConstrainedOncogene491491
543PRDX1peroxiredoxin 11Highly StudiedTrending491491
544MTR5-methyltetrahydrofolate-homocysteine methyltransferase1Hub GeneOMIM Disease Gene489489
545CATcatalase11OMIM Disease GeneHighly Studied488488
546PTPN1protein tyrosine phosphatase non-receptor type 120Highly ConstrainedHighly Studied488488
547SOCS1suppressor of cytokine signaling 116Hub GeneOMIM Disease Gene486486
548F7coagulation factor VII13ProteaseFDA Approved Target485485
549B2Mbeta-2-microglobulin15Hub GeneOMIM Disease Gene484484
550H4C1H4 clustered histone 16Hub GeneHighly Studied484484