Most Researched

Genes ranked by total PubMed publication count — the most-studied genes in biology.

Filter by chromosome
Showing 451500 of 20,598 genes
#GeneNameChrTagsPubMedPubMed Papers
451TGM2transglutaminase 220ProteaseHighly Studied549549
452CD40LGCD40 ligandXHighly ConstrainedHub Gene548548
453P2RX7purinergic receptor P2X 712Ion ChannelReceptor547547
454RIPK1receptor interacting serine/threonine kinase 16ApoptosisHub Gene547547
455CD36CD36 molecule (CD36 blood group)7Hub GeneReceptor546546
456GBA1glucosylceramidase beta 11Clinical TrialsOMIM Disease Gene545545
457HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B17Highly ConstrainedHub Gene544544
458CALCAcalcitonin related polypeptide alpha11FDA Approved TargetHighly Studied542542
459KLF4KLF transcription factor 49Transcription FactorHighly Studied542542
460ADAM17ADAM metallopeptidase domain 172ProteaseClinical Trials541541
461CLTCclathrin heavy chain17Highly ConstrainedHub Gene540540
462HNF1AHNF1 homeobox A12Transcription FactorOMIM Disease Gene540540
463ADAMTS13ADAM metallopeptidase with thrombospondin type 1 motif 139ProteaseOMIM Disease Gene539539
464TSC2TSC complex subunit 216Highly ConstrainedHub Gene539539
465MSH6mutS homolog 62DNA RepairHub Gene538538
466TNFAIP3TNF alpha induced protein 36Highly ConstrainedHub Gene538538
467TXNthioredoxin9Hub GeneTranscription Factor538538
468MAP3K7mitogen-activated protein kinase kinase kinase 76Hub GeneKinase537537
469CASRcalcium sensing receptor3ReceptorFDA Approved Target535535
470HMGA2high mobility group AT-hook 212OncogeneTranscription Factor535535
471LRP1LDL receptor related protein 112Highly ConstrainedReceptor535535
472FCGR2AFc gamma receptor IIa1ReceptorHighly Studied534534
473DKK1dickkopf Wnt signaling pathway inhibitor 110Clinical TrialsHighly Studied533533
474ENGendoglin9Hub GeneClinical Trials533533
475FOSFos proto-oncogene, AP-1 transcription factor subunit14Hub GeneOncogene532532
476SF3B1splicing factor 3b subunit 12Highly ConstrainedHub Gene532532
477ANGPT2angiopoietin 28FDA Approved TargetOMIM Disease Gene531531
478EIF2AK2eukaryotic translation initiation factor 2 alpha kinase 22Hub GeneKinase531531
479PABPC1poly(A) binding protein cytoplasmic 18Highly ConstrainedHub Gene531531
480KLklotho13OMIM Disease GeneHighly Studied529529
481PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 119Highly StudiedTrending529529
482SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B122Highly ConstrainedHub Gene529529
483CNR1cannabinoid receptor 16ReceptorFDA Approved Target528528
484IRF3interferon regulatory factor 319Hub GeneTranscription Factor528528
485JAK1Janus kinase 11Highly ConstrainedHub Gene528528
486S100A8S100 calcium binding protein A81Highly StudiedTrending528528
487TOP1DNA topoisomerase I20Highly ConstrainedOncogene528528
488ENO1enolase 11Hub GeneTranscription Factor526526
489HSP90B1heat shock protein 90 beta family member 112Highly ConstrainedHub Gene526526
490ADARadenosine deaminase RNA specific1OMIM Disease GeneHighly Studied525525
491LDHAlactate dehydrogenase A11Hub GeneOMIM Disease Gene525525
492PRMT5protein arginine methyltransferase 514Highly ConstrainedHub Gene525525
493RPA1replication protein A117DNA RepairHomologous Recombination525525
494FBN1fibrillin 115Highly ConstrainedHub Gene523523
495HNRNPUheterogeneous nuclear ribonucleoprotein U1Highly ConstrainedHub Gene523523
496MAP2K1mitogen-activated protein kinase kinase 115Hub GeneKinase523523
497CCNE1cyclin E119Highly StudiedTrending522522
498CEBPBCCAAT enhancer binding protein beta20Hub GeneTranscription Factor522522
499DDX5DEAD-box helicase 517Highly ConstrainedHub Gene522522
500MRE11MRE11 double strand break repair nuclease11DNA RepairHomologous Recombination522522